article-type : Review Articles
Review Articles
Nucleoside-Modified RNA and Lipid Nanoparticles for "Therapeutic" Use – A Review for Lay People
Volume 1, No 3
Jessica Rose
This accessible review demystifies nucleoside‑modified RNA–lipid nanoparticle (modRNA–LNP) technology, the platform behind COVID‑19 vaccines. It explains how modRNA–LNPs deliver synthetic mRNA to cells, summarizes concerns about rushed clinical trials, waning effectiveness and adverse events, and discusses unanswered questions about long‑term safety and regulatory oversight.
Review Articles
COVID-19 mRNA-Induced "Turbo Cancers"
Volume 1, No 3
Paul Marik, Justus Hope
This review examines reports of unusually aggressive 'turbo cancers' emerging after mass COVID‑19 mRNA vaccination. Drawing on VAERS safety signals and mechanistic studies, the authors describe a multi‑hit hypothesis in which spike protein–mediated metabolic reprogramming, cancer stem‑cell propagation, apoptosis resistance and immune dysregulation may drive rapid tumor growth, and suggest that metabolic and repurposed therapies warrant further research.
Review Articles
Built Different: Functional Sleep Deprivation and the Elite Physician Phenotype
Volume 1, No 3
Joseph Varon
This narrative review explores whether some elite physicians can maintain high performance despite chronic sleep deprivation. Reviewing literature from sleep medicine, neuroscience and critical care, it identifies genetic and neuroplastic adaptations underlying a short‑sleep phenotype, but warns that sustained sleep loss still carries cognitive and physiological risks and urges healthcare systems to reevaluate cultures that normalize extreme endurance.
Review Articles
Pre-existing Immunity to COVID-19: Overview and Implications – Part 1
Volume 1, No 3
Rachel Nicoll
Part one of this three‑part review introduces evidence that prior exposure to common cold coronaviruses and other microbes can generate cross‑reactive T‑ and B‑cell responses against SARS‑CoV‑2. It discusses genetic similarities between human coronaviruses, early studies showing pre‑existing immunity in mucosal tissues, and how trained immunity and cross‑reactive antibodies may influence susceptibility, severity and vaccine design.
Review Articles
The Great PCR and HPAI Mistake
Volume 1, No 3
Roger S. Meacock
This review critiques the widespread use of polymerase chain reaction (PCR) tests as definitive diagnostics in veterinary medicine and in detecting highly pathogenic avian influenza (HPAI). The author explains that PCR amplifies genetic fragments but cannot determine infectivity, highlights false positives when cycles exceed a modest threshold, and warns that misinterpreting results leads to unnecessary culling and misguided disease policies.
Review Articles
Traditional Chinese Medicine (TCM) - A Review (Part 2)
Volume 1, No 2
Pei Harris, Adylle Varon
Part 2 of a comprehensive research review on Traditional Chinese Medicine, examining clinical applications of herbal medicine, Gua Sha, and treatment of Long COVID.
Review Articles
Intravenous Infusions: Past and Present
Volume 1, No 2
Rosapaulina Huerta, Valeria García-Gaytán, Joseph Varon
A historical and clinical review tracing intravenous therapy from ancient transfusions to modern-day innovations in fluid resuscitation and critical care.
Review Articles
Traditional Chinese Medicine (TCM) - A Review (part 1)
Volume 1, No 1
Pei Harris, Adylle Varon
Traditional Chinese Medicine (TCM), with a history spanning over 5,000 years, has gained renewed interest as an alternative treatment during and after COVID-19. This review explores TCM’s history, core theories, and clinical applications, providing insights into acupuncture, moxibustion, and acupressure, alongside traditional and English translations of key TCM concepts and publications.
Review Articles
Ivermectin, a Molecular Swiss Army Knife: A Review of Mechanisms, Indications and Safety Concerns in Drug Repurposing
Volume 1, No 1
Matthew Halma, Paola Vottero
Ivermectin, renowned for treating parasitic diseases, shows promise in addressing broader health challenges, including bacterial, viral, and cancer therapies. With a strong safety profile and no demonstrated reproductive harm, this review underscores its expanding applications while advocating for further research to evaluate its potential benefits and risks in new therapeutic areas.
