Article Type: Review Articles

E-cigarette or Vaping Product Use-Associated Lung Injury (EVALI): A Significant Health Crisis in the Digital World

Volume 2, No 3

Rubi Thapa, Vivek Paudyal, Samina Somji, Munish Sharma, Salim Surani

A review of the epidemiology, diagnosis, and management of EVALI, the severe respiratory illness linked to vaping that emerged as a public health crisis.

Determinants of Autism Spectrum Disorder

Volume 2, No 3

Nicolas Hulscher, John S. Leake, Simon Troupe, Claire Rogers, Kirstin Cosgrove, M. Nathaniel Mead, Breanne Craven, Mila Radetich, Andrew Wakefield, Peter A. McCullough

A comprehensive review identifying genetic, environmental, and iatrogenic determinants of autism, including cumulative early childhood vaccination.

Sepsis Without Biomarkers: A Physiology-Based Approach to Diagnosis and Management in Resource-Limited Settings

Volume 2, No 3

Santiago M. Herrero

A review by Dr. Santiago M. Herrero proposes a physiology-based approach to managing sepsis when biomarkers and advanced diagnostics are unavailable.

Minimizing Signal Loss and Optimizing Pharmacovigilance in VAERS

Volume 2, No 2

Jessica Rose

An analysis of VAERS limitations proposes enhanced data cleaning, advanced signal detection and AI-driven causality assessment to modernize vaccine adverse event reporting.

Evidence-Based Medicine vs Physiology-Based Medicine: A False Dichotomy?

Volume 2, No 2

Santiago M. Herrero

A viewpoint contends that evidence-based and physiology-based medicine are complementary, outlining an integrated framework that merges population evidence with bedside physiology.

Pre-Existing Immunity to COVID-19: Overview and Implications — Part 3

Volume 2, No 2

Rachel Nicoll

Part 3 of this review discusses how non-COVID vaccines and other factors may confer pre-existing immunity to SARS-CoV-2, exploring evidence from observational and clinical studies.

The Myth of the ‘Correct’ Sample Size: Why Formula-Based Justification Misleads Researchers and Reviewers

(Errors and simulations that benefit no one and harm many, depriving them of time and energy)

Volume 2, No 1

L. Prieto-Faliente, C. Carezo Diaz, C. Morin-Barcena

This educational essay contends that formula-based sample-size calculations often mislead researchers and reviewers, arguing that multiple sample sizes can be valid and advocating pragmatic, resource-driven approaches over rigid numeric formulas.

Creatinine-Guided Furosemide Therapy: A Pathophysiological Framework for Precision Diuretic Use in Critically Ill Patients

Volume 2, No 1

Santiago M. Herrero

This review proposes a physiology-based dosing framework for furosemide therapy in critically ill patients, using serum creatinine as a surrogate to guide individualized diuretic dosing and improve safety and efficacy.

RNA:DNA Hybrids Survive Digestion in mRNA Vaccine Manufacturing

Volume 2, No 1

Kevin McKernan, Charles Rixey, Jessica Rose

This study analyzes residual DNA contamination in mRNA vaccines and shows that RNA:DNA hybrids resist DNase digestion during manufacturing, urging improved quality-control assays to quantify and reduce DNA impurities.

Pre-Existing Immunity to COVID-19: Overview and Implications – Part 2

Volume 2, No 1

Rachel Nicoll

Part two of this review explores how exposure to other viruses, parasites and the microbiome influences pre-existing immunity to COVID-19, examining cross-reactivity, protective mechanisms and the role of commensal bacteria.