Chlorine Dioxide as an Adjunctive Treatment in Three Veterinary Cases: A Case Series

Chlorine dioxide has been investigated as an antimicrobial and oxidative agent with applications in water treatment, food safety, and medical sterilization. Despite limited exploration in veterinary medicine, recent research suggests therapeutic potential for complex infectious and neoplastic conditions.

Three cases are presented: (1) a 17-year-old canine with hepatic failure and suspected hepatocellular carcinoma treated with oral fenbendazole and chlorine dioxide enemas; (2) a 6-year-old feline with refractory upper respiratory infection treated with ivermectin and oral sodium chlorite solution; and (3) a 14-year-old canine with an inflammatory mammary mass treated with intratumoral chlorine dioxide injections and oral fenbendazole. All cases showed clinical improvement after initiation of the treatment protocols.

These cases suggest that chlorine dioxide may warrant further investigation as an adjunctive treatment in veterinary medicine. The observed outcomes support the hypothesis that chlorine dioxide’s antimicrobial properties, anti-inflammatory effects, and wound healing promotion may benefit veterinary patients with limited therapeutic options. Controlled studies are needed to establish safety profiles, optimal dosing protocols, and efficacy in veterinary applications.

Keywords: Chlorine dioxide, fenbendazole, ivermectin, veterinary oncology, alternative veterinary medicine, antimicrobial therapy