Article Type: Original Articles
Peer-reviewed studies presenting new clinical data, experimental findings, and groundbreaking medical research.
Original Articles
Integrative Cancer Therapies Addressing Tumoral Metabolic Pathways
Volume 2, No 5
John G. Ionescu, Alexandru Tudor Constantinescu
Drs. John G. Ionescu and Alexandru Tudor Constantinescu review tumor metabolism—redox, alkalinization, the Warburg effect—and integrative therapies targeting it.
Original Articles
Rising Anemia Rates Amidst the COVID-19 Pandemic: Is There A Connection?
Volume 2, No 5
Francesca Martinez-Nachon, Alan Araiza, Jose Iglesias, Joseph Varon
A retrospective cohort study of 136 million US inpatients finds anemia rates rose during the COVID-19 pandemic, but COVID-19 itself was not a major driver.
Original Articles
Convergent Evidence for a Distinct Intravascular Matrix: Integrated Morphological, Elemental, and Proteomic Analysis of Anomalous Intravascular Casts
Volume 2, No 5
Bruce Rapley, Matt Shelton
Integrated histological, elemental (ICP-MS) and proteomic analysis of anomalous intravascular casts reveals a distinct fibrin matrix unlike ordinary clots.
Original Articles
Reanalysis of FDA Clinical Data for mFLUSIVA (mRNA-1010)
Volume 2, No 5
Nicolas Hulscher, Peter A. McCullough, John A. Catanzaro
A reanalysis of FDA clinical trial data for Moderna's mFLUSIVA (mRNA-1010) flu vaccine finds minimal absolute benefit, high reactogenicity and a mortality signal.
Original Articles
Association Between Mitral Valve Disease and Myocarditis in COVID-19 Hospitalizations: A National Inpatient Sample Analysis
Volume 2, No 4
Betzy Santiago Donato, Mohamed Ziad-M. Said, Jose Iglesias, Joseph Varon
A retrospective study using the National Inpatient Sample to assess whether mitral valve disease increases the risk of myocarditis in COVID-19 patients.
Original Articles
The Relationship Between ROX Index and Inflammatory Markers In COVID-19 Patients
Volume 2, No 3
Jorge Martinez, Francesca Martinez-Nachon, Sammy Ghaoui, Paloma A. Molina, Adela Bazbaz, Romina Flores, Joseph Varon
A retrospective study links lower early ROX index values to higher inflammatory burden and worse clinical outcomes in COVID-19 patients on noninvasive support.
Original Articles
Esophageal Cancer Among Gastrointestinal Malignancies in the ICU: A Retrospective Analysis of the MIMIC-III Database
Volume 2, No 3
Magnolia Donaji Garcia Mendoza, Francesca Martinez-Nachon, Jorge Martinez Muñoz, Joseph Varon
A retrospective MIMIC-III analysis finds esophageal cancer is the fourth most common GI malignancy in the ICU, with marked male predominance in older adults.
Original Articles
Association Between Sarcoidosis and Lung Cancer: A Retrospective Analysis
Volume 2, No 2
Julian B. Santiago, Matthew Halma, Arlette Covarrubias, Edgar Selem, Joseph Varon
A cross-sectional US inpatient analysis explores the association between sarcoidosis and lung cancer, finding sarcoidosis linked to lower odds of concurrent lung cancer.
Original Articles
Detection of SARS-CoV-2 from Patient Fecal Samples by Whole Genome Sequencing
Volume 2, No 1
Andreas Papoutsis, Thomas Borody, Siba Dolat, Jordan Daniels, Skylar Steinberg, Brad Barrows, Sabine Hazan
This study employs whole-genome sequencing to detect SARS-CoV-2 in fecal samples from COVID-19 patients, demonstrating 100% concordance with nasopharyngeal RT-PCR and highlighting the potential for fecal-oral transmission.
Original Articles
Impact of Acquired Hypernatremia in the ICU on Mortality in Patients with Acute Respiratory Failure: A Retrospective Analysis from the NIS Database
Volume 2, No 1
Edgar Selemi, Jose Iglesias, Matthew Halma, Joseph Varon
This original study uses data from the National Inpatient Sample to evaluate how ICU-acquired hypernatremia affects mortality and length of stay in patients with acute respiratory failure, identifying higher mortality and comorbidity-specific risks.